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Module:
Mutation Impact
Step 1: Select Cancer and Mutation type
Mutation type
All mutation
 
Non-synonymous mutation
Cancer type
Close
ACC: Adrenocortical Carcinoma (n=92)
BLCA: Bladder Urothelial Carcinoma (412)
BRCA: Breast Invasive Carcinoma (n=1098)
CESC: Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (n=307)
CHOL: Cholangiocarcinoma (n=51)
COAD: Colon Adenocarcinoma (n=461)
DLBC: Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (n=58)
ESCA: Esophageal Carcinoma (n=185)
GBM: Glioblastoma Multiforme (n=617)
HNSC: Head and Neck Squamous Cell Carcinoma (n=528)
KICH: Kidney Chromophobe (n=113)
KIRC: Kidney Renal Clear Cell Carcinoma (n=537)
KIRP: Kidney Renal Papillary Cell Carcinoma(n=291)
LAML: Acute Myeloid Leukemia (n=200)
LGG: Brain Lower Grade Glioma (n=516)
LIHC: Liver Hepatocellular Carcinoma (n=377)
LUAD: Lung Adenocarcinoma (n=585)
LUSC: Lung Squamous Cell Carcinoma (n=504)
MESO: Mesothelioma (n=87)
OV: Ovarian Serous Cystadenocarcinoma (n=608)
PAAD: Pancreatic Adenocarcinoma (n=185)
PCPG: Pheochromocytoma and Paraganglioma (n=179)
PRAD: Prostate Adenocarcinoma (n=500)
READ: Rectum Adenocarcinoma (n=172)
SARC: Sarcoma (n=261)
SKCM: Skin Cutaneous Melanoma (n=470)
STAD: Stomach Adenocarcinoma (n=443)
TGCT: Testicular Germ Cell Tumors (n=150)
THCA: Thyroid Carcinoma (n=507)
THYM: Thymoma (n=124)
UCEC: Uterine Corpus Endometrial Carcinoma (n=560)
UCS: Uterine Carcinosarcoma (57)
UVM: Uveal Melanoma (80)
ACC
BLCA
BRCA
CESC
CHOL
COAD
DLBC
ESCA
GBM
HNSC
KICH
KIRC
KIRP
LAML
LGG
LIHC
LUAD
LUSC
MESO
OV
PAAD
PCPG
PRAD
READ
SARC
SKCM
STAD
TGCT
THCA
THYM
UCEC
UCS
UVM
Step 2: Input Genes
OR
Upload File
OR
Cancer pathways-gene lists
(
10 - 350 genes per pathway
)
Step 3: Advanced Options
FDR <
AND
OR
Absolute Fold Change
Overall Survival
(
runtime: ~30sec per cancer
)
Hierarchical clustering and heatmap
(
runtime: ~30sec per cancer,
Number of genes > 1
)
Cross-Cancer Comparison
(
runtime: ~30sec per 2 cancer,
2 <= Number of cancer type selected <= 5
)
Mutation Impact Ranking
(
runtime: ~30sec per cancer
)
Pathway | GeneOntology
(
runtime: ~1min per gene
)
KEGG
Wikipathway
Biological Process
Cellular Component
Molecular Function
DAVID