Welcome to the CoMutDB database !
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TCGA
Brain
Brain Lower Grade Glioma
Heart
Brain Lower Grade Glioma
Breast
Breast Invasive Carcinoma
Pancreas
Pancreatic Adenocarcinoma
Kidney
Kidney Chromophobe

Kidney Renal Clear Cell Carcinoma

Kidney Renal Papillary Cell Carcinoma
Adrenal Gland
Adrenocortical Carcinoma
Bladder
Bladder Urothelial Carcinoma
Testis
Testicular Germ Cell Tumors
Prostate
Prostate Adenocarcinoma
Eye
Uveal Melanoma
Lung
Lung Adenocarcinoma

Lung Squamous Cell Carcinoma
Thyroid
Thyroid Carcinoma
Bile Ducts
Cholangiocarcinoma
Stomach
Stomach Adenocarcinoma
Liver
Liver Hepatocellular Carcinoma
Intestine
Colon Adenocarcinoma

Rectum Adenocarcinoma
Blood
Acute Myeloid Leukemia
Cervix
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma

Ovarian Serous Cystadenocarcinoma

Uterine Corpus Endometrial Carcinoma

Uterine Carcinosarcoma

Cancer List:
Select the cancers from which the mutation-expression associations were inferred. You can select up to 5 cancers by clicking an item in the list and repeat the process. Cancers can also be selected by clicking on the organ icons on the human figure on the left. The selected cancers appear in the Selected cancers area.



Selected cancer Types:

  • Adrenocortical Carcinoma (ACC)×
  • Bladder Urothelial Carcinoma (BLCA)×
  • Breast Invasive Carcinoma (BRCA)×
  • Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC)×
  • Cholangiocarcinoma (CHOL)×
  • Colon Adenocarcinoma (COAD)×
  • Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC)×
  • Esophageal Carcinoma (ESCA)×
  • FFPE Pilot Phase II (FPPP)×
  • Head and Neck Squamous Cell Carcinoma (HNSC)×
  • Kidney Chromophobe (KICH)×
  • Kidney Renal Clear Cell Carcinoma (KIRC)×
  • Kidney Renal Papillary Cell Carcinoma (KIRP)×
  • Acute Myeloid Leukemia (LAML)×
  • Brain Lower Grade Glioma (LGG)×
  • Liver Hepatocellular Carcinoma (LIHC)×
  • Lung Adenocarcinoma (LUAD)×
  • Lung Squamous Cell Carcinoma (LUSC)×
  • Mesothelioma (MESO)×
  • Ovarian Serous Cystadenocarcinoma (OV)×
  • Pancreatic Adenocarcinoma (PAAD)×
  • Pheochromocytoma and Paraganglioma (PCPG)×
  • Prostate Adenocarcinoma (PRAD)×
  • Rectum Adenocarcinoma (READ)×
  • Sarcoma (SARC)×
  • Skin Cutaneous Melanoma (SKCM)×
  • Stomach Adenocarcinoma (STAD)×
  • Testicular Germ Cell Tumors (TGCT)×
  • Thyroid Carcinoma (THCA)×
  • Thymoma (THYM)×
  • Uterine Corpus Endometrial Carcinoma (UCEC)×
  • Uterine Carcinosarcoma (UCS)×
  • Uveal Melanoma (UVM)×

Paste genes:

OR Upload a file about genes:
supporting csv or txt file!

Example
 

OR Select gene set by pathway:
An user can select gene set from a predefined pathways

Survival:
Whether to conduct survival analysis

 Yes     

Phenotype:
Whether to output co-mutation analysis based on race, age, or gender.

 Race       Age       Gender     

Single Mutation Frequency:
Whether to output single mutation frequencies

 Yes     

Mutation Type:
Silent: mutations that do not alter amino acid; Nonsilent: mutations that alter amino acid; All: include both silent and nonsilent mutations.

 silent       nonsilent       all

Co-mutation logic:
And: all genes specified in the input must be mutated; Or: only one gene from the specified input needs to be mutated; Synergy: linear model k1x1 + k2x2 + k3x1x2 also used to analysis the association between co-mutation and phenotype.

 And       Or       Synergy

Co-mutation gene limit:
The upper limit of co-mutated genes. This number indicates how many genes needs to be mutated simultaneously to be considered co-mutated. The upper limit is set as 4. However, the number of input genes can be greater than 4. For example, if 20 genes are inputted and 4 is selected here, all combination of 4 genes from the 20 genes will be tested.

 2     3     4   

Survival Type:
DSS = disease specific survival; DFI = disease free interval; PFI = progression free interval; OS = overall survival

 DSS    DFI    PFI     OS  

Co-mutation significance
Evaluate statistical significance of co-mutation via biRewire algorithm. Please expect lengthy running time due to intensive computation. The resultant comut_P is included in tables.

 Yes