Welcome to the CoMutDB database !
 Home  TCGA  ICGC  DepMap  Download  Help  Contact  Innove Bioinformatics

DepMap
Brain(N = 103)
Breast(N = 67)
Pancreatic(N = 57)
Kidney(N = 53)
Bladder(N = 39)
Prostate(N = 13)
Lung(N = 266)
Thyroid(N = 21)
Bile Duct(N = 36)
Gastric(N = 46)
Liver(N = 27)
Colon/Colorectal(N = 79)
Leukemia(N = 132)
Ovarian(N = 73)
Cervical(N = 21)
Endometrial/Uterine(N = 39)

Cancer List:
Select the cancers from which the mutation-expression associations were inferred. You can select up to 5 cancers by clicking an item in the list and repeat the process. Cancers can also be selected by clicking on the organ icons on the human figure on the left. The selected cancers appear in the Selected cancers area.



Selected cancer Types:

  • Bile Duct(N = 36)×
  • Bladder(N = 39)×
  • Bone(N = 73)×
  • Brain(N = 103)×
  • Breast(N = 67)×
  • Cervical(N = 21)×
  • Colon/Colorectal(N = 79)×
  • Endometrial/Uterine(N = 39)×
  • Engineered(N = 13)×
  • Esophageal(N = 38)×
  • Fibroblast(N = 42)×
  • Gastric(N = 46)×
  • Head and Neck(N = 75)×
  • Kidney(N = 53)×
  • Leukemia(N = 132)×
  • Liposarcoma(N = 11)×
  • Liver(N = 27)×
  • Lung(N = 266)×
  • Lymphoma(N = 108)×
  • Myeloma(N = 35)×
  • Neuroblastoma(N = 46)×
  • Ovarian(N = 73)×
  • Pancreatic(N = 57)×
  • Prostate(N = 13)×
  • Rhabdoid(N = 20)×
  • Sarcoma(N = 37)×
  • Skin(N = 110)×
  • Thyroid(N = 21)×

Paste genes:

OR Upload a file about genes:
supporting csv or txt file!

Example
 

OR Select gene set by pathway:
An user can select gene set from a predefined pathways

Drug sensitivity
Whether to output drug sensitivity

 Yes     

Single Mutation Frequency:
Whether to output single mutation frequencies

 Yes     

Mutation Type
Silent: mutations that do not alter amino acid; Nonsilent: mutations that alter amino acid; All: include both silent and nonsilent mutations.

 silent       nonsilent       all

Co-mutation logic:
And: all genes specified in the input must be mutated; Or: only one gene from the specified input needs to be mutated; Synergy: linear model k1x1 + k2x2 + k3x1x2 also used to analysis the association between co-mutation and phenotype.

 And       Or       Synergy

Co-mutation gene limit:
The upper limit of co-mutated genes. This number indicates how many genes needs to be mutated simultaneously to be considered co-mutated. The upper limit is set as 4. However, the number of input genes can be greater than 4. For example, if 20 genes are inputted and 4 is selected here, all combination of 4 genes from the 20 genes will be tested.

 2     3     4   

Co-mutation significance
Evaluate statistical significance of co-mutation via biRewire algorithm. Please expect lengthy running time due to intensive computation. The resultant comut_P is included in tables.

 Yes