Binding motifs for transcription factors, RNA binding proteins and microRNAs, etc. are vital for proper gene transcription. Sequence altering mechanisms can cause either gain or loss of important binding motifs and thereby lead to severe consequences such as tumorigenesis. Efficient identification of somatic alterations in DNA motifs can provide important insights into the mechanism underlying aberrant gene transcription in human tumors, and thus offer novel cancer therapeutic hypotheses. Altered binding sequences can arise from single nucleotide mutations, insertion, deletion, RNA editing, or single nucleotide polymorphism (SNP). The SomaticMotif, as an easy online tool for annotating and identifying altered binding motifs, supports personalized genome approach, customizable motif regions, and a wide selection of species.
Release 2.0 (2020-10-12)
Release 1.0 (2020-03-13)